Within 60 adenoma samples (median age 67 years) successfully amplified by qMSP, promoter hypermethylation was detected in 90%, 68%, 42%, 85% and 55% for CNRIP1, FBN1, INA, MAL, and SNCA, respectively, and 90% of the adenomas harbored co-methylation. Here, INA is linked to adenoma.