Methylation in colorectal cancers ranged from 55% (C3orf14) to 96% (BEX1; median 84%), while methylation in normal tissue was between 0% (CNRIP1, FBN1, INA) and 45% (BEX1; median 5%), P < 0.0001 to P < 0.02. This evidence concerns the gene FBN1 and colorectal cancer.