More detailed analyses of the 13 APS patients with ischemic stroke and/or TIA also revealed a significant higher prevalence of anti-PI IgM (3/13) and anti-CL IgM (9/13) antibodies compared with the remaining APS patients (0/72, P = 0.002826; 24/72, P = 0.027352; respectively). This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.