Patients suffering from APS demonstrated a significantly higher frequency of anti-CL IgG (P < 0.000001, respectively), anti-CL IgM (ELISA: P < 0.000001, respectively; MLDA: P < 0.000001, P = 0.0002, respectively), anti-β2 GPI IgG (P < 0.000001, respectively) and anti-β2 GPI IgM (ELISA: P < 0.000001, respectively; MLDA: P < 0.000001, P = 0.000049, respectively) compared to DC patients and NHS in both ELISA and MLDA. Here, APOH is linked to autoimmune polyendocrinopathy.