As HCV is associated with many extra hepatic complications, decline of Hb level with the increase of viral load in HCV may lead to autoimmune haemolytic anemia (AIHA) that can contribute to enhance the liver cirrhosis especially in patients with genotypes 1-4 as the patients with HCV related AIHA have higher prevalence of cirrhosis [31]. The gene discussed is GSTM1; the disease is autoimmune hemolytic anemia.