We undertook an association analysis of 3 functional polymorphisms in the promoter of the MMP-2 gene (-1306C/T, -1575G/A and -790T/G), to investigate the possible role for MMP-2 as a genetic risk factor for obesity (in terms of increased PBF) in the ABC study. This evidence concerns the gene MMP2 and obesity due to melanocortin 4 receptor deficiency.