THOP1 and early-onset autosomal dominant Alzheimer disease: The unique pathways identified in the hippocampus were acute myeloid leukemia signaling; hypoxia signaling in the cardiovascular system; neuroprotective role of thimet oligopeptidase 1 (THOP1) in Alzheimer's disease; retinoic acid mediated apoptosis signaling; thyroid cancer signaling; and urea cycle and metabolism of amino groups (Additional File 10).