However, three main points make it difficult to use kinase inhibitors as anti-schistosome compound when compared to PZQ: (1) unlike most kinase inhibitors, PZQ is generally well tolerated; (2) PZQ represents a low-cost medicine, whereas cancer drugs such as Imatinib are still expensive, and (3) in particular, protein kinases share very similar structural and functional features, making it more difficult to design a specific inhibitor. Here, WEE1 is linked to cancer.