In fact, recent studies [49, 50] have identified a population of CD8α+ T-cell receptor (TCR)− facilitating cells (FCs) that enhance allo-Bmt engraftment and tolerance, and decrease GvHD, and have characterized the main subpopulation of FC as plasmacytoid precursor dendritic cells (p-preDCs) which can induce antigen-specific Treg. The gene discussed is CD8A; the disease is graft versus host disease.