Klangsinsirikul et al. have supported the previous findings by showing that the elimination of the host Apcs diminishes the intensity of GvHD [45], while Sato and colleagues have shown that host-derived regulatory DC (Dcreg) generated in vitro that express Mhc Class II and lack expression of immune costimulatory molecules were more effective in preventing GvHD than classic tolerogenic DC, through the induction of T-cell anergy due to diminished co-stimulation, despite the presence of a potent antigenic signal [46, 47]. The gene discussed is APCS; the disease is graft versus host disease.