Indeed, three of the top four genes up-regulated at the TB interface (i.e., receptor activator of NF-kB ligand, Rankl; integrin binding sialoprotein, Ibsp; and matrix metalloproteinase 13, Mmp13) are well established as mediators of bone metastasis [7,11-13,15,41,42]. This evidence concerns the gene MMP13 and tuberculosis.