PDGFR is class III subfamily of RTKs including five receptors i.e. PDGFR-α, PDGFR-β, CSF-IR (colony stimulating factor 1 receptor), cKIT and FLT3 involved in cellular growth, differentiation, cytokine vascular regulation, gliomas and leukemia [3, 17]. The gene discussed is PDGFRB; the disease is central nervous system cancer.