Here, we evaluated caspase-cleaved CK18 and hyaluronic acid as biomarkers for NAFLD and fibrosis in a cohort of 127 patients who underwent bariatric surgery and compared these results to the histological diagnosis, quantified by NAFLD-activity score (NAS), as established by Kleiner et al. [10]. This evidence concerns the gene KRT18 and metabolic dysfunction-associated steatotic liver disease.