TZDs are antidiabetic drugs, and so a concern would be the possible exacerbation of the hypoglycemia commonly seen in severe malaria; however, rosiglitazone and other TZDs function as insulin sensitizers and are generally not known to cause hypoglycemia, and as mentioned above, rosiglitazone did not cause hypoglycemia in patients with uncomplicated malaria [111]. This evidence concerns the gene INS and malaria.