EWSR1 and sarcoma: In the eighth paper, “Tyrosine phosphorylation in the C-terminal nuclear localization and retention signal (C-NLS) of the EWS protein,” R. P. Leemann-Zakaryan et al., describe the role of C-terminal phosphorylation in physiological control of EWS nuclear localization, which is lost upon rearrangement with a transcription factor moiety in sarcoma.