Effects of HPN on leukocyte subsets in lungs and BALF were marked with change in numbers of CD3+ T cells, CD4+ helper T cells, Gr-1+/CD11b+ granulocytes, CD3−/CCR3+ eosinophils, CD3+/CCR3+ Th2 cells, CD3+/CD69+ early activated T cells, B220+/CD23+ B cells in a mouse model of asthma compared to control group, and the deficits in CD3−/CCR3+ eosinophils were accompanied by concurrent decreases eosinophils in BALF cytospin (Figure 2(d)). The gene discussed is CCR3; the disease is asthma.