We compared nuclear KIAA1199 protein expression with nuclear β-catenin expression in the same cores of our CRC TMA, as nuclear β-catenin corresponds to active Wnt/β-catenin signalling in vivo. Remarkably, 69% (25 out of 36) of the tumours with strong nuclear and weak cytoplasmic KIAA1199 localization showed nuclear β-catenin localization, compared with 51% (106 out of 209) of the tumours with cytoplasmic KIAA1199 expression only (Supplementary Figure 6b). Here, CEMIP is linked to colorectal carcinoma.