While these findings, along with evidence of eIF4E overexpression in human cancers (Flowers et al, 2009; Graff et al, 2009; Wang et al, 2009), support the notion that eIF4E is oncogenic, a direct connection between eIF4E and translational deregulation downstream of oncogenic AKT signalling has only recently been described. The gene discussed is AKT1; the disease is cancer.