We have shown in human tumor cells that BRCA1 directly affects the GGR subpathway of NER, and that this function may occur through transcriptional regulation of NER genes involved in the recognition of adducts in genomic DNA, including XPC and DDB2 (the genes mutated in xeroderma pigmentosum complementation groups C and E, respectively) [13]. Here, BRCA1 is linked to neoplasm.