For instance, thiazolidinediones (TZDs) such as rosiglitazone and pioglitazone, which induce PGC-1α expression and activate the PPARγ pathway have been shown to be beneficial in the SOD1 transgenic mouse model of ALS by two independent research groups [29,30]. This evidence concerns the gene PPARGC1A and amyotrophic lateral sclerosis.