Taking into account the possible influence that ACP1 may have in the susceptibility to immune-mediated disorders and in the pathogenesis of the CV disease, in the present study we aimed to investigate the possible association of ACP1 alleles with the susceptibility to RA as well as whether ACP1 gene polymorphism may contribute to the increased risk of CV complications observed in patients with RA. Here, ACP1 is linked to rheumatoid arthritis.