Ironically, in several plant-virus pathosystems, close relationships between defense responses to virus infection and severe necrotic symptoms have been reported [3-7]; these defense responses are thought to involve a hypersensitive response (HR) and programmed cell death (PCD), which are mediated by recognition of virus infection through a resistance (R) gene, which encodes a nucleotide-binding-leucine-rich repeat (NB-LRR) protein that detects a specific viral avirulence (Avr) gene. The gene discussed is NLRP6; the disease is viral infectious disease.