Recently, however, in an interesting study by Rickles and coworkers using a high throughput screening (cHTS) platform to identify new drugs to combine with existing therapeutic strategies for multiple myeloma [42], it was discovered that the agonist of the adenosine A2A receptor as well as phosphodiesterase (PDE) inhibitors synergized with glucocorticoids to inhibit cell proliferation and induce death of multiple myeloma cells [42], thereby supporting our present results. This evidence concerns the gene ADORA2A and plasma cell myeloma.