In this explorative study of 373 SNPs, mainly located in pathways related to lipid and glucose metabolism, we found a significant association between the Ile405Val genotype in the CETP gene and the Cys112Arg genotype in the APOE gene, with multiple features of the metabolic syndrome, i.e. the prevalence of abdominal obesity and prevalence of low HDL-cholesterol. The gene discussed is CETP; the disease is Abdominal obesity.