Interestingly, the human locus with the highest LOD score for autism susceptibility (D2S2188 on chromosome 2q) maps very close to the gene encoding for the GABA synthesized enzyme GAD65 and to Dlx1 and Dlx2. Furthermore, the autism susceptibility locus D7S477 on chromosome 7q maps within about six megabases of Dlx5 and Dlx6 which are implicated in the regulation of forebrain GABAergic neurons [98]. This evidence concerns the gene GAD2 and autism.