NGF and early-onset autosomal dominant Alzheimer disease: Moreover, dysfunctions in the mechanisms driving nerve-growth factor (NGF) retrograde transport from the hippocampus to the basal forebrain [94, 95] are responsible for a prominent degeneration of basal forebrain cholinergic neurons in adult Ts65Dn mice [96], which is also a hallmark of the Alzheimer's disease.