The salient findings of our study are: (a) TSP50 is abnormally highly expressed in CRCs in comparison with colorectal adenomas and normal tissues; (b) TSP50 expression is unrelated to p53 expression in CRC; (c) TSP50 overexpression distinguishes CRCs from colorectal adenomas and normal tissues with high specificity and PPV; and (d) high TSP50 expression in CRC is a novel independent factor for unfavorable prognosis. The gene discussed is PRSS50; the disease is colorectal adenoma.