PRSS50 and colorectal adenoma: The significant increase of TSP50 overexpression observed in CRCs (65 of 95 cases, 68.4%) as compared to colorectal adenomas and normal tissues (3 of 40 cases, 8%) is an important finding of our study, but there is no obvious correlation between TSP50 expression in CRCs and the clinicopathologic features (Table 2).