Antibodies used for immunohistochemistry can detect both the wild-type and the mutated p53 protein, and TSP50 expression is significantly higher in breast cancer cells in which p53 gene is mutated [4], so TSP50 expression might be correlated with the status of p53 gene but not with the accumulated quantity of p53 protein in CRC. This evidence concerns the gene PRSS50 and breast carcinoma.