Since the circulating levels of these factors have been found to be increased in autoimmune disease [8], [13], we analyzed a subgroup of AE patients to elucidate whether their specific IgE levels to human MnSOD (n = 5) [19] correlated with the circulating levels of these cytokines, however, no correlation was found (data not shown). Here, SOD2 is linked to autoimmune disease.