These differences between our study and the study by Zimmermann et al[15] could besides different immuno-staining protocols and source of anti-TWEAK and anti-Fn14 mAb possibly be due to the source of healthy skin; they used non-lesional skin from the buttock area of patients with AE or psoriasis, whereas we used skin biopsy specimens from healthy individuals. This evidence concerns the gene TNFRSF12A and psoriasis.