IGHE and acrodermatitis enteropathica: Although the exact role of B-cells in AE is not fully understood, the contribution of B-cells to AE etiopathogenesis has become evident by studies showing that B-cell-depleting treatment with anti-CD20 Ab improved AE skin lesions with reduced mRNA expression of IL-5 and IL-13 and decreased infiltration of T and B-cells in skin, whereas total and allergen-specific IgE levels were not reduced, suggesting other functions than Ab production of B-cells in the disease mechanisms [5].