The implications for a therapy of RP in this model are important since these results suggest that targeting exclusively the caspase cascade – as was previously proposed for the rd1 mouse [33] - is unlikely to give positive results while, on the other hand, targeting non-apoptotic events such as calpain or PARP activation may have beneficial effects [20], [28]. This evidence concerns the gene PDE6B and retinitis pigmentosa 1.