NEDD9 overexpression is frequent in glioblastomas [13], melanomas [14], and some lung cancers [15], and promotes metastasis; upregulation of NEDD9 also promotes oncogenic signaling in the hematopoietic system [16], [17], [18], [19], [20], and supports invasive behavior in breast cancer cell lines [21], while genetic ablation of NEDD9 limits mammary tumor growth in the MMTV-polyomavirus middle T (PyVT) model of tumorigenesis [22], [23]. The gene discussed is NEDD9; the disease is melanoma.