UBE3A and cervical carcinoma: The expression of viral oncoproteins E6 in HPV-positive cervical carcinomas [6] can interact with the E6-associated protein (E6AP) to form E6/E6AP complex that specifically induces the ubiquitination and rapid degradation of p53, nuclear transcription factor X-box binding 91 (NFX1-91) and PDZ domain-containing proteins through the proteasome pathway [7], [8], [9], [10].