In summary, although the role of LH in the progression of ovarian cancer is still controversial, it is well documented that LH-mediated signaling affects many microRNAs, genes and pathways in the LHR+ SKOV3 cells, and the indicative clues of inhibiting apoptosis and regulating cell proliferation may direct further research and help elucidate causes, detection and treatment of ovarian cancer. The gene discussed is PLOD1; the disease is ovarian cancer.