Some of these genes were differentially expressed in the response to LH binding to LHR+ cancer cells, including those involved in the regulation of cell migration and proliferation (such as IRS1, IRS2, IL6R, TPM1, GLI1, BMPR2 and GRN), cell surface receptor-linked signal transduction (SOCS5 and RAF1), anti-apoptosis (FAS, MCL1 and SGK3) and transcription regulation (DNMT3B, GLI1 and EZH2), as shown in Table 1. Here, IRS2 is linked to cancer.