However, in diabetic NOD mice, the CD4+CD25+Foxp3+ T cell proportions were much higher than that in any other group (5.42 ± 0.83%, 8.11 ± 1.6%, 20.63 ± 5.79% in the spleen, intestinal lymph nodes, and blood, resp., P < .05), and we believe that this was a result of a T1D autoimmune feedback mechanism. This evidence concerns the gene CD4 and type 1 diabetes mellitus.