Cluster 1 comprises 767 differentially expressed genes, and the following genes were highlighted because they participate in immune processes potentially implicated in the pathogenesis of T1D: IL4, involved with T-cell activation, Crtam, involved in cytotoxicity and Tlr3, Tlr4, and Tlr6, involved in inflammatory response. Here, TLR4 is linked to type 1 diabetes mellitus.