The gene expression in these cells could be considered to occur in the first stage of T1D, and this expression features the down-regulation of genes involved with the activation of the immune system/adaptive response, cell activation, NF-KappaB cascade, immune effector/immune response processes, inflammatory response, lymphocyte activation, the regulation of interferon-gamma production, the regulation of leukocyte-mediated cytotoxicity, apoptosis, cell communication, and signal transduction. The gene discussed is IFNG; the disease is type 1 diabetes mellitus.