However, since 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) activity is greater in OC tissue compared to normal ovarian tissue [103], it is not surprising that OC cell lines treated with IL-1α  in vitro induced 11βHSD2 gene expression leading to the reverse conversion of cortisol to cortisone inactivating the anti-inflammatory actions of 11βHSD1 and, thereby, supporting tumor cell proliferation [104]. This evidence concerns the gene IL1A and neoplasm.