GP1BA and infective endocarditis: Binding of these SRR adhesins to platelets is a high affinity process, with the interaction between GspB and glycocalicin having a KD of 2.38×10−8 M [11] and appears to be a major factor in the pathogenesis of infective endocarditis, since the loss of GspB or Hsa expression results in a marked reduction in virulence [33].