VWF and Plasmodium falciparum malaria: Additional causes of impairedmicrovascular flow and organ dysfunction in falciparum malaria include dysregulatedimmune responses (32),endothelial activation with elevated angiopoietin-2 and von Willebrand factor (33,34), and decreased vascularnitric oxide bioavailability (25) and red cell deformability (35), but their roles in knowlesi malariaremain unknown.