CD52 and autoimmune disease: Accordingly, therapeutic approaches to treat autoimmune diseases that involve either decreasing Teff populations (e.g. through chemotherapy, anti-CD52 or anti-CD20 mAb therapy) or increasing Treg populations (e.g. Treg cell therapy) will not cure the disease, since they are aimed to keep the values of both populations in the range observed in healthy state but without restoring the control of the immune system to that of the healthy state.