In a randomized controlled trial, 31% - 44% of healthy young participants experienced an ALT level greater than 3 times the upper limit of the normal range (ULN) and more than 19% of participants experienced ALT more than five times the ULN during treatment with paracetamol at a dose of 4 g per day for 14 days, although none developed symptoms or laboratory evidence of hepatic failure [11]. The gene discussed is GPT; the disease is Hepatic failure.