ERBB2 and breast carcinoma: Such studies have shown that the molecular profile of breast cancer present a systematic variation which allowed its differential identification into two distinct branches [11], the ER-positive branch, comprising the luminal A and B subtypes, and three ER-negative branch, which comprises at least, two reproducible subtypes: the HER2-overexpressing group and the basal-like group [6,8,9,13-15].