Moreover, various studies have indicated that failure of the adaptive immune response, including Th1 hypo-responsiveness, CD8+ CTL exhaustion, excessive function of CD4+ CD25+ FOXP3+ regulatory T cells, and failure of lymphoid cell via direct binding and/or infection in B cells, T cells, and DCs occurs in CHC patients [9–21]. The gene discussed is CD4; the disease is cryohydrocytosis.