Based on the analysis of 137 cases of HCC from France and China, Laurent-Puig et al. [18] have proposed a model that distinguishes two main pathways of HCC, one characterized by chromosome instability, TP53 mutations, Axin 1 mutations, HBV infection, poor differentiation, and poor prognosis, and the other characterized by chromosomal stability, CTNNB1 mutations, absence of HBV, and tendency to form large tumors. This evidence concerns the gene AXIN1 and hepatocellular carcinoma.