TP53 and hepatocellular carcinoma: Based on the analysis of 137 cases of HCC from France and China, Laurent-Puig et al. [18] have proposed a model that distinguishes two main pathways of HCC, one characterized by chromosome instability, TP53 mutations, Axin 1 mutations, HBV infection, poor differentiation, and poor prognosis, and the other characterized by chromosomal stability, CTNNB1 mutations, absence of HBV, and tendency to form large tumors.