Advanced CML stage (hazard ratio 4.0, P<.001), resistance or intolerance to imatinib (hazard ratio 5.4, P = .002) and hypermethylation of the PDLIM4 gene (hazard ratio 2.7, P = 0.003) were independent prognostic variables (Table 6 and Figure 4). Here, PDLIM4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.