The relationship between increased CCL2 expression and disease progression and severity has been linked to a single nucleotide polymorphism (SNP) located at position -2578 in the distal promoter of CCL2 in diseases such as pulmonary tuberculosis, HCV-related liver disease, and HIV-associated dementia [14], [24], [25], [26], [27]. This evidence concerns the gene CCL2 and pulmonary tuberculosis.