In animal experiments of endotoxemia dual ETA/ETB endothelin blockade has been described to improve cardiopulmonary function [4], reduce pulmonary hypertension [5] and lung injury [6], attenuate intestinal microcirculatory dysfunction [7], reduce intestinal acidosis [8], [9] and improve renal function [10]. Here, EDNRB is linked to serum lipopolysaccharide activity.