Moreover, we recently reported that viruses did not evolve early to become sCD4 sensitive in macaques that were depleted of B cells to abrogate or diminish antiviral antibody responses prior to infection with SHIVSF162P3N, implying that the reduced antibody-driven pressure in the RPs was also not sufficient to select for viruses with an “open” Env conformation [104]. Here, ERVW-1 is linked to infection.