Interestingly, a role for MMPs during malaria is suggested also by evidence from nonhuman models of CM: in the brain of mice infected by P. Berghei ANKA, the etiological agent of murine CM, increased MMP-2, MMP-7, and MMP-9 levels, and pro-MMP-9 activation were found [18, 19]. Here, MMP9 is linked to malaria.