Despite initial studies showing anabolic effects, principally gains of lean body mass, improvements in grip strength, quality of life, and reductions in IL-6 and PIF could be achieved in a variety of cancers [99], including pancreatic cancer [112, 113], lung cancer [114], and colorectal cancer [115], analysis of RCTs only, using the Cochrane approach, did not show any differences between EPA supplementation and placebo [39]. Here, IL6 is linked to cancer.