Since PTEN is mutated in autosomal inherited disorders with phenotypes similar to those of PJS (Bannayan-Riley-Ruvalcaba syndrome and Cowden disease), there appears to be a functional link between the proteins involved in different hamartomatous polyposis syndromes, thus, emphasizing the central role played by LKB1 as a tumor suppressor in the intestine [14]. The gene discussed is PTEN; the disease is Cowden disease.