A number of clinical studies have also been published during recent years where the role of IFNAR1 expression has been correlated with the response to IFN-α therapy in chronic hepatitis C. The studies conducted by Taniguchi et al., [29] indicated that high intrahepatic mRNA levels of IFNAR1 and the ratio of IFNAR1 to IFNAR2 were significantly higher in patients having a sustained viral response (SVR) to IFN-α therapy. This evidence concerns the gene IFNAR2 and chronic hepatitis C virus infection.