However, while STOX1A expression is found primarily in the brain and dysregulation of the balance between glial 4R/3R tau ratio by a selective increase in either 3R-tau or 4R-tau is commonly seen in a range of diverse neurodegenerative diseases other than LOAD, including frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), Pick's disease (PD), progressive supranuclear palsy (PSP), and corticobasal degeneration [22], further exploration of where STOX1A and/or SFRS7 expression are found in these neurodegenerative diseases would yield great insight of their involvement. This evidence concerns the gene MAPT and neurodegenerative disease.