It is well known that Twist is reactivated in different types of tumors and it is considered to play a key role in the development and progression of human cancer, being associated with advanced tumor stage and poor prognosis in rhabdomyosarcoma, gastric carcinoma, melanoma, glioma, liver carcinoma and breast, prostate, bladder and pancreatic cancer [37]; [52], [53]; [36], [54]. This evidence concerns the gene TWIST1 and melanoma.