The role of IKKα in cancer development remains controversial: while it has been suggested that it functions as a tumor suppressor in skin cancer [4], [12], [13], there are also evidences that support a role of IKKα as promoter of cancer progression and metastasis in different types of neoplasias such as breast cancer [14], hepatocarcinomas [15], prostate cancer [16], [17] and colorectal cancer [18], [19]. The gene discussed is CHUK; the disease is skin cancer.