CD40 and breast neoplasm: A distinct pattern of activation of NF-κB subunits (c-Rel, RelB, p50/ NF-κB1, p52/ NF-κB2, and Iκ-Bα), as well as the absence (or low level) of nuclear p65/RelA has also been previously described in breast tumors, as compared to normal adjacent tissue [22], [48].